Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain

Abstract excerpt

Vectors derived from adeno-associated virus (AAV) are promising candidates for neural cell transduction in vivo because they are nonpathogenic and achieve long-term transduction in the central nervous system. AAV serotype 2 (AAV2) is the most widely used AAV vector in clinical trials based largely on its ability to transduce neural cells in the rodent and primate brain. Prior work in rodents suggests that other...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Viral gastroenteritis research and epidemiology
• Share to Viral Infections and Immunology Research
• Share to Virus-based gene therapy research