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ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries

19 Feb 2016

Abstract excerpt

Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Nonetheless, the role of RA has been disputed principally because germ cells in embryos lacking two major RA-synthesizing enzymes, ALDH1A2 and...

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PMID: 26892828
DOI: 10.1038/ncomms10845

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