FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.

doi:10.1182/blood-2009-09-242859

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Article

FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.

Blood - 18 Feb 2010

Pratz Keith W, Sato Takashi, Murphy Kathleen M, Stine Adam, Rajkhowa Trivikram, Levis Mark

Abstract excerpt

We examined 6 different FMS-like tyrosine kinase-3 (FLT3) inhibitors (lestaurtinib, midostaurin, AC220, KW-2449, sorafenib, and sunitinib) for potency against mutant and wild-type FLT3, as well as for cytotoxic effect against a series of primary blast samples obtained from patients with acute myeloid leukemia (AML) harboring internal tandem duplication (FLT3/ITD) mutations. We found that inhibition of FLT3...

Topics

Alleles
Antineoplastic Agents
Benzenesulfonates
Benzothiazoles
Carbazoles
Cell Death
Cell Line, Tumor
Drug Resistance, Neoplasm
Furans
Humans
Indazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Indoles

Leukemia, Myeloid, Acute

Mutation

Niacinamide

Phenylurea Compounds

Phosphorylation

Piperazines

Source

Open in PubMed Open full text

Identifiers

PMID: 20007803
DOI: 10.1182/blood-2009-09-242859
PMCID: PMC2826764

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20007803-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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