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Article

Effects of normalization on quantitative traits in association test.

BMC bioinformatics - 14 Dec 2009

Goh Liang, Yap Von Bing

Abstract excerpt

BACKGROUND: Quantitative trait loci analysis assumes that the trait is normally distributed. In reality, this is often not observed and one strategy is to transform the trait. However, it is not clear how much normality is required and which transformation works best in association studies. RESULTS: We performed simulations on four types of common quantitative traits to evaluate the effects of normalization using...

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Identifiers

PMID: 20003414
DOI: 10.1186/1471-2105-10-415
PMCID: PMC2800123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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