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Article

The longitudinal nonparametric test as a new tool to explore gene-gene and gene-time effects in cohorts.

Genetic epidemiology - 1 Jul 2010

Malzahn D, Schillert A, Müller M, Bickeböller H

Abstract excerpt

Current approaches for analysis of longitudinal genetic epidemiological data of quantitative traits are typically restricted to normality assumptions of the trait. We introduce the longitudinal nonparametric test (LNPT) for cohorts with quantitative follow-up data to test for overall main effects of genes and for gene-gene and gene-time interactions. The LNPT is a rank procedure and does not depend on normality...

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PMID: 20568282
DOI: 10.1002/gepi.20500

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