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Article

Methylation status of<i>IGFBP-3</i>as a useful clinical tool for deciding on a concomitant radiotherapy

2 Nov 2014

Abstract excerpt

The methylation status of the IGFBP-3 gene is strongly associated with cisplatin sensitivity in patients with non-small cell lung cancer (NSCLC). In this study, we found in vitro evidence that linked the presence of an unmethylated promoter with poor response to radiation. Our data also indicate that radiation might sensitize chemotherapy-resistant cells by reactivating IGFBP-3-expression through promoter...

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Identifiers

PMID: 25482372
DOI: 10.4161/15592294.2014.971626

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