Article
Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon.
Oncogene - 1 Feb 1991
D'Emilia J C, Mathey-Prevot B, Jaros K, Wolf B, Steele G, Summerhayes I C
Abstract excerpt
With the use of viral vectors harboring myc and src oncogenes, we have assessed the potential contribution of these different elements to colonic neoplasia using a transplantation technique resulting in the formation of a heterotopic colon in Wistar Furth rats. While myc alone induced atypia and some dysplasia, src induced focal dysplastic lesions throughout the colon mucosa with evidence of metaplasia. In...
Topics
- Animals
- Colon
- Colonic Neoplasms
- Genes, myc
- Genes, src
- Phenotype
- Precancerous Conditions
- Rats
- Rats, Inbred Strains
- Retroviridae