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Article

Genetic changes including gene copy number alterations and their relation to prognosis in childhood acute myeloid leukemia.

Leukemia & lymphoma - 1 Jan 2010

Armengol Gemma, Canellas Anna, Alvarez Yolanda, Bastida Pilar, Toledo José Sánchez De, Pérez-Iribarne Maria Del Mar, Camós Mireia, Tuset Esperanza, Estella Jesús, Coll María Dolores, Caballín María Rosa, Knuutila Sakari

Abstract excerpt

We studied a series of 68 subjects diagnosed with childhood acute myeloid leukemia (AML) using conventional cytogenetics and fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR) to analyze mutations in FLT3 and NPM1 genes, and/or array comparative genomic hybridization (CGH). Cytogenetic/FISH abnormalities were observed in 71% of subjects, FLT3-ITD mutations in 15%, and NPM1 mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 20001230
DOI: 10.3109/10428190903350397

Genes

FLT3
NPM1
AKT1
JAK2
LTB
RUNX1
RUNX1T1
SDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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