Article
Loss at 12p detected by comparative genomic hybridization (CGH): association with TEL-AML1 fusion and favorable prognostic features in childhood acute lymphoblastic leukemia (ALL). A multi-institutional study.
Medical and pediatric oncology - 1 Nov 2001
Kanerva J, Niini T, Vettenranta K, Riikonen P, Mäkipernaa A, Karhu R, Knuutila S, Saarinen-Pihkala U M
Abstract excerpt
BACKGROUND: Genetic aberrations provide prognostic information in childhood ALL. The proportion of patients with detectable aberrations can be increased by combining G-banding with comparative genomic hybridization (CGH). PROCEDURE: We studied 79 children with ALL by CGH and G-banding, and explored the relationship of these findings to clinical features and outcome. RESULTS: CGH revealed DNA copy number changes...
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