Article
The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci.
PloS one - 4 Dec 2009
Wain Louise V, Pedroso Inti, Landers John E, Breen Gerome, Shaw Christopher E, Leigh P Nigel, Brown Robert H, Tobin Martin D, Al-Chalabi Ammar
Abstract excerpt
BACKGROUND: The genetic contribution to sporadic amyotrophic lateral sclerosis (ALS) has not been fully elucidated. There are increasing efforts to characterise the role of copy number variants (CNVs) in human diseases; two previous studies concluded that CNVs may influence risk of sporadic ALS, with multiple rare CNVs more important than common CNVs. A little-explored issue surrounding genome-wide CNV...
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