Article
Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach.
Molecular neurobiology - 1 Feb 2018
Morello Giovanna, Guarnaccia Maria, Spampinato Antonio Gianmaria, La Cognata Valentina, D'Agata Velia, Cavallaro Sebastiano
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a devastating and still untreatable motor neuron disease. Despite the molecular mechanisms underlying ALS pathogenesis that are still far from being understood, several studies have suggested the importance of a genetic contribution in both familial and sporadic forms of the disease. In addition to single-nucleotide polymorphisms (SNPs), which account for only a limited...
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