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Article

Parsing the effects of individual SNPs in candidate genes with family data.

Human heredity - 1 Jan 2010

Hoffmann Thomas J, Lange Christoph, Vansteelandt Stijn, Raby Benjamin A, DeMeo Dawn L, Silverman Edwin K, Weiss Scott T, Laird Nan M

Abstract excerpt

We introduce a stepwise approach for family-based designs for selecting a set of markers in a gene that are independently associated with the disease. The approach is based on testing the effect of a set of markers conditional on another set of markers. Several likelihood-based approaches have been proposed for special cases, but no model-free based tests have been proposed. We propose two types of tests in a...

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Identifiers

PMID: 19996607
DOI: 10.1159/000264447
PMCID: PMC2956011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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