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Article

Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers.

Journal of virology - 1 Feb 2012

Mehle Andrew, Dugan Vivien G, Taubenberger Jeffery K, Doudna Jennifer A

Abstract excerpt

The emergence of new pandemic influenza A viruses requires overcoming barriers to cross-species transmission as viruses move from animal reservoirs into humans. This complicated process is driven by both individual gene mutations and genome reassortments. The viral polymerase complex, composed of the proteins PB1, PB2, and PA, is a major factor controlling host adaptation, and reassortment events involving...

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Identifiers

PMID: 22090127
DOI: 10.1128/JVI.06203-11
PMCID: PMC3264373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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