Recombination between <i>ccrC</i> Genes in a Type V (5C2&amp;5) Staphylococcal Cassette Chromosome <i>mec</i> (SCC <i>mec</i> ) of <i>Staphylococcus aureus</i> ST398 Leads to Conversion from Methicillin Resistance to Methicillin Susceptibility <i>In Vivo</i>

Abstract excerpt

Various types of the staphylococcal cassette chromosome mec (SCCmec) are known to confer methicillin resistance on the human pathogen Staphylococcus aureus. Such cassettes are not always stably maintained. The present studies were aimed at identifying the mechanism underlying the in vivo conversion of methicillin-resistant S. aureus (MRSA) to methicillin-susceptible S. aureus (MSSA) derivatives as encountered in...

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