Detection of Staphylococcal Cassette Chromosome <i>mec</i> Type XI Carrying Highly Divergent <i>mecA</i> , <i>mecI</i> , <i>mecR1</i> , <i>blaZ</i> , and <i>ccr</i> Genes in Human Clinical Isolates of Clonal Complex 130 Methicillin-Resistant <i>Staphylococcus aureus</i>

Abstract excerpt

Methicillin resistance in staphylococci is mediated by penicillin binding protein 2a (PBP 2a), encoded by mecA on mobile staphylococcal cassette chromosome mec (SCCmec) elements. In this study, two clonal complex 130 (CC130) methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients in Irish hospitals were identified that were phenotypically PBP 2a positive but lacked mecA by conventional PCR and...

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