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Direct Induction of Chondrogenic Cells from Human Dermal Fibroblast Culture by Defined Factors

16 Oct 2013

Abstract excerpt

The repair of large cartilage defects with hyaline cartilage continues to be a challenging clinical issue. We recently reported that the forced expression of two reprogramming factors (c-Myc and Klf4) and one chondrogenic factor (SOX9) can induce chondrogenic cells from mouse dermal fibroblast culture without going through a pluripotent state. We here generated induced chondrogenic (iChon) cells from human dermal...

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PMID: 24146984
DOI: 10.1371/journal.pone.0077365

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