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Article

Pathogenesis of type 1 diabetes: implications for incidence trends.

Hormone research in paediatrics - 1 Jan 2011

Knip Mikael

Abstract excerpt

BACKGROUND: The incidence of type 1 diabetes (T1D) has increased markedly after World War II among children and adolescents, while the mean age at diagnosis has decreased. These trends support a critical role of exogenous factors in the development of T1D, since genetic factors alone can hardly explain the rapid increase. Evidence supporting a crucial role of environmental determinants in the pathogenesis of T1D...

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PMID: 21778751
DOI: 10.1159/000329169

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