Article
Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants.
Experimental and clinical psychopharmacology - 1 Dec 2009
Hamidovic Ajna, Dlugos Andrea, Skol Andrew, Palmer Abraham A, de Wit Harriet
Abstract excerpt
The dopamine D2 receptor (DRD2) appears to be involved in impulsive behaviors, and particularly in behavioral inhibition. We sought to determine whether inhibition and impulsivity were related to genetic polymorphisms in the DRD2 gene (DRD2) in healthy volunteers (N = 93). Participants received placebo or d-amphetamine in random order. They performed the stop task, measuring behavioral inhibition, and rated their...
Topics
- Adolescent
- Adult
- Affect
- Analysis of Variance
- Central Nervous System Stimulants
- Dextroamphetamine
- Dose-Response Relationship, Drug
- Double-Blind Method
- Exploratory Behavior
- Female