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Article

Cost function network-based design of protein-protein interactions: predicting changes in binding affinity.

Bioinformatics (Oxford, England) - 1 Aug 2018

Viricel Clément, de Givry Simon, Schiex Thomas, Barbe Sophie

Abstract excerpt

Motivation: Accurate and economic methods to predict change in protein binding free energy upon mutation are imperative to accelerate the design of proteins for a wide range of applications. Free energy is defined by enthalpic and entropic contributions. Following the recent progresses of Artificial Intelligence-based algorithms for guaranteed NP-hard energy optimization and partition function computation, it...

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PMID: 29474517
DOI: 10.1093/bioinformatics/bty092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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