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Article

Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge.

Journal of lipid research - 1 May 2010

Cho Joo-Youn, Matsubara Tsutomu, Kang Dong Wook, Ahn Sung-Hoon, Krausz Kristopher W, Idle Jeffrey R, Luecke Hans, Gonzalez Frank J

Abstract excerpt

Farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in synthesis, metabolism, and transport of bile acids and thus plays a major role in maintaining bile acid homeostasis. In this study, metabolomic responses were investigated in urine of wild-type and Fxr-null mice fed...

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Identifiers

PMID: 19965603
DOI: 10.1194/jlr.M002923
PMCID: PMC2853433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-19965603-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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