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Article

Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity.

Archives of toxicology - 1 Apr 2014

Liu Aiming, Krausz Kristopher W, Fang Zhong-Ze, Brocker Chad, Qu Aijuan, Gonzalez Frank J

Abstract excerpt

Gemfibrozil, a ligand of peroxisome proliferator-activated receptor α (PPARα), is one of the most widely prescribed anti-dyslipidemia fibrate drugs. Among the adverse reactions observed with gemfibrozil are alterations in liver function, cholestatic jaundice, and cholelithiasis. However, the mechanisms underlying these toxicities are poorly understood. In this study, wild-type and Ppara-null mice were dosed with...

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Identifiers

PMID: 24385052
DOI: 10.1007/s00204-013-1188-0
PMCID: PMC6398607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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