Article
The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.
Thrombosis and haemostasis - 1 Nov 2008
Liu Xiaoli, Li Yun, Wang Laiyuan, Zhao Qi, Lu Xiangfeng, Huang Jianfeng, Fan Zhongjie, Gu Dongfeng
Abstract excerpt
Dyslipidemia, especially hypercholesterolemia, is a major risk factor of coronary heart disease (CHD). The insulin induced gene 1 (INSIG1) and insulin induced gene 2 (INSIG2) encode two proteins which mediate feedback control of cholesterol synthesis. We conducted a case-control study to investigate whether the common variants in INSIG genes were associated with CHD in Chinese Han population. Three single...
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