Article
Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis.
Pancreas - 1 Mar 2010
Witt Heiko, Rosendahl Jonas, te Morsche René H M, Santhosh Sundaresan, Chacko Ashok, Schulz Hans-Ulrich, Landt Olfert, Teich Niels, Keim Volker, Mössner Joachim, Gress Thomas M, Ockenga Johann, Schmidt Hartmut, Kovacs Peter, Blüher Matthias, Stumvoll Michael, Kage Andreas, Groneberg David Alexander, Jansen Jan B M J, Nickel Renate, Drenth Joost P H
Abstract excerpt
OBJECTIVES: Premature activation of pancreatic digestive enzymes is considered as a major factor in the pathogenesis of pancreatitis. Genetic alterations of different pancreatic zymogens or their inhibitors have been associated with chronic pancreatitis (CP). METHODS: We sequenced all 12 GP2 exon...
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