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Article

Loss of oriented cell division does not initiate cyst formation.

Journal of the American Society of Nephrology : JASN - 1 Feb 2010

Nishio Saori, Tian Xin, Gallagher Anna Rachel, Yu Zhiheng, Patel Vishal, Igarashi Peter, Somlo Stefan

Abstract excerpt

Polycystic kidney disease (PKD) can arise from either developmental or postdevelopmental processes. Recessive PKD, caused by mutations in PKHD1, is a developmental defect, whereas dominant PKD, caused by mutations in PKD1 or PKD2, occurs by a cellular recessive mechanism in mature kidneys. Oriented cell division is a feature of planar cell polarity that describes the orientation of the mitotic axes of dividing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19959710
DOI: 10.1681/ASN.2009060603
PMCID: PMC2834544

Genes

PKD1
PKD2
PKHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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