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Article

Loss of oriented cell division does not initiate cyst formation.

Journal of the American Society of Nephrology : JASN - 1 Feb 2010

Nishio Saori, Tian Xin, Gallagher Anna Rachel, Yu Zhiheng, Patel Vishal, Igarashi Peter, Somlo Stefan

Abstract excerpt

Polycystic kidney disease (PKD) can arise from either developmental or postdevelopmental processes. Recessive PKD, caused by mutations in PKHD1, is a developmental defect, whereas dominant PKD, caused by mutations in PKD1 or PKD2, occurs by a cellular recessive mechanism in mature kidneys. Orient...

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Share to Cell Division
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules

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Source

Open in PubMed Open full text

Identifiers

PMID: 19959710
DOI: 10.1681/ASN.2009060603
PMCID: PMC2834544

Genes

PKD1
PKD2
PKHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19959710-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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