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Article

Silencing of Claudin-11 Is Associated with Increased Invasiveness of Gastric Cancer Cells

23 Nov 2009

Abstract excerpt

BACKGROUND: Claudins are membrane proteins that play critical roles in tight junction (TJ) formation and function. Members of the claudin gene family have been demonstrated to be aberrantly regulated, and to participate in the pathogenesis of various human cancers. In the present study, we report that claudin-11 (CLDN11) is silenced in gastric cancer via hypermethylation of its promoter region....

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Identifiers

PMID: 19956721
DOI: 10.1371/journal.pone.0008002

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