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Article

Hypomethylation of CLDN4 Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer.

International journal of molecular sciences - 10 Jun 2022

Maesaka Fumisato, Kuwada Masaomi, Horii Shohei, Kishi Shingo, Fujiwara-Tani Rina, Mori Shiori, Fujii Kiyomu, Mori Takuya, Ohmori Hitoshi, Owari Takuya, Miyake Makito, Nakai Yasushi, Tanaka Nobumichi, Bhawal Ujjal Kumar, Luo Yi, Kondoh Masuo, Fujimoto Kiyohide, Kuniyasu Hiroki

Abstract excerpt

The tight junction (TJ) protein claudin-4 (CLDN4) is overexpressed in bladder urothelial carcinoma (BUC) and correlates with cancer progression. However, the mechanism of CLDN4 upregulation and promotion of malignant phenotype is not clear. Here, we analyzed 157 cases of BUC and investigated the hypomethylation of CpG island in the CLDN4 promoter DNA and its correlation with cancer progression. In hypomethylated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35742959
DOI: 10.3390/ijms23126516
PMCID: PMC9224287

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