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Article

Impact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line.

PloS one - 1 Jan 2011

Costa Natália R, Paulo Paula, Caffrey Thomas, Hollingsworth Michael A, Santos-Silva Filipe

Abstract excerpt

BACKGROUND: Gastric carcinoma is the second leading cause of cancer-associated death worldwide. The high mortality associated with this disease is in part due to limited knowledge about gastric carcinogenesis and a lack of available therapeutic and prevention strategies. MUC1 is a high molecular weight transmembrane mucin protein expressed at the apical surface of most glandular epithelial cells and a major...

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Source

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Identifiers

PMID: 22073229
DOI: 10.1371/journal.pone.0026970
PMCID: PMC3206881

Genes

MUC1
ADAM29
KLK6
TCN1
TSPAN8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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