Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Redox regulation of RhoA.

Biochemistry - 5 Dec 2006

Heo Jongyun, Raines Kimberly W, Mocanu Viorel, Campbell Sharon L

Abstract excerpt

We have previously shown that redox agents including superoxide anion radical and nitrogen dioxide can react with GXXXXGK(S/T)C motif-containing GTPases (i.e., Rac1, Cdc42, and RhoA) to stimulate guanine nucleotide release. We now show that the reaction of RhoA with redox agents leads to different functional consequences from that of Rac1 and Cdc42 due to the presence of an additional cysteine (GXXXCGK(S/T)C) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Cisplatin
Share to Guanine Nucleotides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kinetics

Share to Mass Spectrometry

Share to Nitric Oxide

Share to Oxidation-Reduction

Share to rhoA GTP-Binding Protein

Source

Identifiers

PMID: 17128987
DOI: 10.1021/bi0610101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Redox regulation of RhoA.PMID 17128987Read ↗

Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif.Semantic proximity Read ↗

Regulation of redox signalling by an electrophilic cyclic nucleotideSemantic proximity Read ↗

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.Semantic proximity Read ↗

Plant rac proteins induce superoxide production in mammalian cells.Semantic proximity Read ↗

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.Semantic proximity Read ↗

A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival.Semantic proximity Read ↗

Rac1 regulates stress-induced, redox-dependent heat shock factor activation.Semantic proximity Read ↗

Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors.Semantic proximity Read ↗

Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.Semantic proximity Read ↗

A novel role for RhoGDI as an inhibitor of GAP proteins.Semantic proximity Read ↗

Rac-related GTP-binding protein in elicitor-induced reactive oxygen generation by suspension-cultured soybean cells.Semantic proximity Read ↗

Requirements for the different cysteines in the chemotactic and desensitizing activity of human thioredoxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.