Article
Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores.
PloS one - 30 Nov 2009
Aguilar Jorge L, Kulkarni Ritwij, Randis Tara M, Soman Sandeep, Kikuchi Alexander, Yin Yuxin, Ratner Adam J
Abstract excerpt
Diverse bacterial species produce pore-forming toxins (PFT) that can puncture eukaryotic cell membranes. Host cells respond to sublytic concentrations of PFT through conserved intracellular signaling pathways, including activation of mitogen-activated protein kinases (MAPK), which are critical to cell survival. Here we demonstrate that in respiratory epithelial cells p38 and JNK MAPK were phosphorylated within 30...
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