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Article

Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores.

PloS one - 30 Nov 2009

Aguilar Jorge L, Kulkarni Ritwij, Randis Tara M, Soman Sandeep, Kikuchi Alexander, Yin Yuxin, Ratner Adam J

Abstract excerpt

Diverse bacterial species produce pore-forming toxins (PFT) that can puncture eukaryotic cell membranes. Host cells respond to sublytic concentrations of PFT through conserved intracellular signaling pathways, including activation of mitogen-activated protein kinases (MAPK), which are critical to...

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Identifiers

PMID: 19956644
DOI: 10.1371/journal.pone.0008076
PMCID: PMC2778951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19956644-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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