Article
4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion.
PloS one - 2 Dec 2009
Ravindran Sandeep, Lodoen Melissa B, Verhelst Steven H L, Bogyo Matthew, Boothroyd John C
Abstract excerpt
Toxoplasma gondii is a eukaryotic parasite of the phylum Apicomplexa that is able to infect a wide variety of host cells. During its active invasion process it secretes proteins from discrete secretory organelles: the micronemes, rhoptries and dense granules. Although a number of rhoptry proteins have been shown to be involved in important interactions with the host cell, very little is known about the mechanism...
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