Article
Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Feb 2010
Hiroi Maiko, Morishita Yoshiaki, Hayashi Masayuki, Ozaki Nobuaki, Sugimura Yoshihisa, Nagasaki Hiroshi, Shiota Akira, Oiso Yutaka, Arima Hiroshi
Abstract excerpt
Familial neurohypophysial diabetes insipidus (FNDI) is a rare disease that is inherited in an autosomal dominant manner. In a previous study, we made a mouse model for FNDI, which showed progressive polyuria accompanied by inclusion bodies in the arginine vasopressin (AVP) neurons formed by aggregates in the endoplasmic reticulum. The present study was conducted to determine whether the activities of AVP neurons...
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