Article
Activation of vasopressin neurons leads to phenotype progression in a mouse model for familial neurohypophysial diabetes insipidus.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Feb 2010
Hiroi Maiko, Morishita Yoshiaki, Hayashi Masayuki, Ozaki Nobuaki, Sugimura Yoshihisa, Nagasaki Hiroshi, Shiota Akira, Oiso Yutaka, Arima Hiroshi
Abstract excerpt
Familial neurohypophysial diabetes insipidus (FNDI) is a rare disease that is inherited in an autosomal dominant manner. In a previous study, we made a mouse model for FNDI, which showed progressive polyuria accompanied by inclusion bodies in the arginine vasopressin (AVP) neurons formed by aggre...
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