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Article

Mechanisms underlying progressive polyuria in familial neurohypophysial diabetes insipidus.

Journal of neuroendocrinology - 1 Jul 2010

Arima H, Oiso Y

Abstract excerpt

Familial neurohypophysial diabetes insipidus (FNDI), an autosomal dominant disorder, is mostly caused by mutations in the gene of neurophysin II (NPII), the carrier protein of arginine vasopressin (AVP). The analyses of knock-in mice expressing a mutant NPII that causes FNDI in humans demonstrated that polyuria progressed substantially in the absence of loss of AVP neurones. Morphological analyses revealed that...

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Identifiers

PMID: 20492364
DOI: 10.1111/j.1365-2826.2010.02028.x

Genes

AVP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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