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Article

Human cancers converge at the HIF-2α oncogenic axis

2 Dec 2009

Abstract excerpt

Cancer development is a multistep process, driven by a series of genetic and environmental alterations, that endows cells with a set of hallmark traits required for tumorigenesis. It is broadly accepted that growth signal autonomy, the first hallmark of malignancies, can be acquired through multiple genetic mutations that activate an array of complex, cancer-specific growth circuits [Hanahan D, Weinberg RA (2000)...

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PMID: 19955413
DOI: 10.1073/pnas.0906432106

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