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Article

Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.

Pharmacogenetics and genomics - 1 Jan 2010

Azzato Elizabeth M, Chen Renee A, Wacholder Sholom, Chanock Stephen J, Klebanoff Mark A, Caporaso Neil E

Abstract excerpt

OBJECTIVES: The teratogenic effects of the anti-epileptic drug phenytoin have been linked to genetic differences in phenytoin disposition. The goal of this study was to assess the effect of maternal genotype of functional polymorphisms in two genes involved in phenytoin metabolism, CYP2C9 (R144C,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19952982
DOI: 10.1097/FPC.0b013e328334b6a3

Genes

EPHX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19952982-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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