Article
Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone.
Journal of molecular histology - 1 Oct 2009
Tezval Mohammad, Tezval Hossein, Dresing Klaus, Stuermer Ewa Klara, Blaschke Martina, Stuermer Klaus Michael, Siggelkow Heide
Abstract excerpt
Urocortin-1 (UCN) a corticotropin releasing-factor (CRF) related peptide, has been found to be expressed in many different tissues like the central nervous system, the cardiovascular system, adipose tissue, and skeletal muscle. The effects of UCN are mediated via stimulation of CRF-receptors 1 and 2 (CRFR1 and 2, CRFR's) with a high affinity for CRFR2. It has been shown that the CRF-related peptides and CRFR's...
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