Article
The influence of the acyl chain composition of cardiolipin on the stability of mitochondrial complexes; an unexpected effect of cardiolipin in alpha-ketoglutarate dehydrogenase and prohibitin complexes.
Journal of proteomics - 10 Feb 2010
van Gestel Renske A, Rijken Pieter J, Surinova Silvia, O'Flaherty Martina, Heck Albert J R, Killian J Antoinette, de Kroon Anton I P M, Slijper Monique
Abstract excerpt
The role of cardiolipin acyl chain composition in assembly/stabilization of mitochondrial complexes was investigated using three yeast deletion mutants (acb1Delta strain; taz1Delta strain; and acb1Deltataz1Delta strain). Deletion of the TAZ1 gene, involved in cardiolipin acyl chain remodeling, is known to increase the content of monolyso-cardiolipin (MLCL) at the expense of CL, and to decrease the unsaturation of...
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