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Article

Neutrophil elastase-processing defect in cyclic hematopoietic dogs.

Experimental hematology - 1 Feb 2010

Meng Ronghua, Bridgman Roger, Toivio-Kinnucan Maria, Niemeyer Glenn P, Vernau William, Hock Tommy, Lothrop Clinton D

Abstract excerpt

OBJECTIVE: Canine cyclic hematopoiesis (CH), a model of human cyclic neutropenia and severe congenital neutropenia, is characterized by a periodic reduced neutrophil count and decreased neutrophil elastase (NE) enzymatic activity. Canine CH is caused by a mutation of AP3B1 encoding the beta3A subunit of adaptor protein complex-3 (AP-3). It has been proposed that trafficking of elastase is affected by AP-3. The...

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Identifiers

PMID: 19941936
DOI: 10.1016/j.exphem.2009.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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