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Article

Functional and structural effects of an Ala to Val mutation in the adenovirus serotype 2 fibre.

Journal of molecular biology - 5 Feb 1991

Caillet-Boudin M L, Lemay P, Boulanger P

Abstract excerpt

H2ts125 is a fibre-defective, temperature-sensitive mutant of adenovirus serotype 2. H2ts125 fibre is unstable at the non-permissive temperature (ts phenotype), and does not migrate in the same way as the wild-type fibre in an SDS/polyacrylamide gel (elm phenotype). Sequence analysis has shown that H2ts125 carries two mutations on the fibre gene: Leu105 to Phe, and Ala434 to Val. Analysis of the structural...

Topics

Adenoviruses, Human
Blotting, Western
Capsid
Capsid Proteins
Microscopy, Electron
Molecular Weight
Mutation
Oligopeptides
Peptide Fragments
Protein Conformation
Protein Denaturation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Solubility

Structure-Activity Relationship

Temperature

Source

Identifiers

PMID: 1994035
DOI: 10.1016/0022-2836(91)90751-q

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1994035-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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