Article
Phenotypic plasticity of mouse spermatogonial stem cells.
PloS one - 19 Nov 2009
Morimoto Hiroko, Kanatsu-Shinohara Mito, Takashima Seiji, Chuma Shinichiro, Nakatsuji Norio, Takehashi Masanori, Shinohara Takashi
Abstract excerpt
BACKGROUND: Spermatogonial stem cells (SSCs) continuously undergo self-renewal division to support spermatogenesis. SSCs are thought to have a fixed phenotype, and development of a germ cell transplantation technique facilitated their characterization and prospective isolation in a deterministic manner; however, our in vitro SSC culture experiments indicated heterogeneity of cultured cells and suggested that they...
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