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Article

Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.

American journal of human genetics - 1 Dec 2009

Yang Quanhe, Flanders W Dana, Moonesinghe Ramal, Ioannidis John P A, Guessous Idris, Khoury Muin J

Abstract excerpt

Personal genome tests are now offered direct-to-consumer (DTC) via genetic variants identified by genome-wide association studies (GWAS) for common diseases. Tests report risk estimates (age-specific and lifetime) for various diseases based on genotypes at multiple loci. However, uncertainty surrounding such risk estimates has not been systematically investigated. With breast cancer as an example, we examined the...

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Identifiers

PMID: 19931039
DOI: 10.1016/j.ajhg.2009.10.017
PMCID: PMC2790579

Genes

FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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