Article
Role of serum amyloid P component for systemic amyloidosis in transgenic mice carrying human mutant transthyretin gene.
Gerontology - 1 Jan 1991
Tashiro F, Yi S, Wakasugi S, Maeda S, Shimada K, Yamamura K
Abstract excerpt
The role of serum amyloid P component (SAP) for systemic amyloidosis in a transgenic mouse model for an autosomal dominant disease, familial amyloidotic polyneuropathy (FAP), was examined. For this purpose, two lines of transgenic mouse were produced by introducing the human mutant transthyretin...
Topics
- Age Factors
- Amyloidosis
- Animals
- Disease Models, Animal
- Female
- Gene Expression
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Nervous System Diseases
- Prealbumin
- Serum Amyloid P-Component
- Tissue Distribution