Article
Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy.
Human mutation - 1 Dec 2005
Taylor Matthew R G, Slavov Dobromir, Gajewski Andreas, Vlcek Sylvia, Ku Lisa, Fain Pamela R, Carniel Elisa, Di Lenarda Andrea, Sinagra Gianfranco, Boucek Mark M, Cavanaugh Jean, Graw Sharon L, Ruegg Patsy, Feiger Jennie, Zhu Xiao, Ferguson Debra A, Bristow Michael R, Gotzmann Josef, Foisner Roland, Mestroni Luisa
Abstract excerpt
Thymopoietin or TMPO (indicated by its alternative gene symbol, LAP2, in this work) has been proposed as a candidate disease gene for dilated cardiomyopathy (DCM), since a LAP2 product associates with nucleoplasmic lamins A/C, which are encoded by the DCM gene LMNA. We developed a study to screen for genetic mutations in LAP2 in a large collection of DCM patients and families. A total of 113 subjects from 88...
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