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Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart

16 Nov 2009

Abstract excerpt

Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood. When functioning normally, mature heart valves prevent intracardiac retrograde blood flow; before valves develop, there is considerable regurgitation, resulting in reversing (or oscillatory) flows between the atrium and ventricle. As...

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PMID: 19924233
DOI: 10.1371/journal.pbio.1000246

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