Article
Novel xenograft and cell line derived from an invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into molecular mechanisms.
Pancreas - 1 Apr 2010
Fritz Stefan, Fernández-del Castillo Carlos, Iafrate A John, Mino-Kenudson Mari, Neyhard Nancy, LaFemina Jennifer, Stirman Amy, Warshaw Andrew L, Thayer Sarah P
Abstract excerpt
OBJECTIVES: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are a unique entity with malignant potential. Histologically, pancreatic ductal adenocarcinoma (PDAC) arising in IPMN (intraductal papillary mucinous carcinoma [IPMC]) appears similar to sporadic PDAC; biologically, however, IPMC seems to have a less aggressive clinical course. Little is known about the genetic signature of IPMC. In this...
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