Article
Distinction of Invasive Carcinoma Derived From Intraductal Papillary Mucinous Neoplasms From Concomitant Ductal Adenocarcinoma of the Pancreas Using Molecular Biomarkers.
Pancreas - 1 Jul 2016
Tamura Koji, Ohtsuka Takao, Date Kenjiro, Fujimoto Takaaki, Matsunaga Taketo, Kimura Hideyo, Watanabe Yusuke, Miyazaki Tetsuyuki, Ohuchida Kenoki, Takahata Shunichi, Ishigami Kousei, Oda Yoshinao, Mizumoto Kazuhiro, Nakamura Masafumi, Tanaka Masao
Abstract excerpt
OBJECTIVES: To clarify the usefulness of molecular biomarkers for distinguishing invasive carcinoma derived from intraductal papillary mucinous neoplasms (IPMNs [Inv-IPMN]) from concomitant pancreatic ductal adenocarcinoma (PDAC). METHODS: Data from 19 patients with resected concomitant PDAC were retrospectively reviewed. KRAS/GNAS mutations and immunohistochemical (IHC) expression of p53 and p16/CDKN2A were...
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