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Article

Phenotype-genotype studies in kuru: implications for new variant Creutzfeldt-Jakob disease.

Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 1998

Cervenáková L, Goldfarb L G, Garruto R, Lee H S, Gajdusek D C, Brown P

Abstract excerpt

The PRNP polymorphic (methionine/valine) codon 129 genotype influences the phenotypic features of transmissible spongiform encephalopathy. All tested cases of new variant Creutzfeldt-Jakob disease (nvCJD) have been homozygous for methionine, and it is conjectural whether different genotypes, if they appear, might have distinctive phenotypes and implications for the future "epidemic curve" of nvCJD....

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Identifiers

PMID: 9789072
DOI: 10.1073/pnas.95.22.13239
PMCID: PMC23768

Genes

PRNP

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Phenotype-genotype studies in kuru: implications for new variant Creutzfeldt-Jakob disease.PMID 9789072Read ↗

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Increased susceptibility to Kuru of carriers of the PRNP 129 methionine/methionine genotype.Semantic proximity Read ↗

Defining the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease MV2K: the kuru plaque type.Semantic proximity Read ↗

A novel subtype of sporadic Creutzfeldt-Jakob disease with PRNP codon 129MM genotype and PrP plaques.Semantic proximity Read ↗

Clinicopathological phenotype of codon 129 valine homozygote sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Comparative neuropathology of Kuru with the new variant of Creutzfeldt-Jakob disease: evidence for strain of agent predominating over genotype of host.Semantic proximity Read ↗

Neuropathologic variants of sporadic Creutzfeldt-Jakob disease and codon 129 of PrP gene.Semantic proximity Read ↗

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