Article
Phenotype-genotype studies in kuru: implications for new variant Creutzfeldt-Jakob disease.
Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 1998
Cervenáková L, Goldfarb L G, Garruto R, Lee H S, Gajdusek D C, Brown P
Abstract excerpt
The PRNP polymorphic (methionine/valine) codon 129 genotype influences the phenotypic features of transmissible spongiform encephalopathy. All tested cases of new variant Creutzfeldt-Jakob disease (nvCJD) have been homozygous for methionine, and it is conjectural whether different genotypes, if t...
Topics
- Adolescent
- Adult
- Age of Onset
- Amyloid
- Child
- Chromosomes, Human, Pair 20
- Codon
- Creutzfeldt-Jakob Syndrome
- DNA
- Female
- Genetic Variation
- Genotype
- Humans
- Kuru
- Male
- Methionine
- Middle Aged
- Papua New Guinea