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Article

Mutations in classical swine fever virus NS4B affect virulence in swine.

Journal of virology - 1 Feb 2010

Fernandez-Sainz I, Gladue D P, Holinka L G, O'Donnell V, Gudmundsdottir I, Prarat M V, Patch J R, Golde W T, Lu Z, Zhu J, Carrillo C, Risatti G R, Borca M V

Abstract excerpt

NS4B is one of the nonstructural proteins of classical swine fever virus (CSFV), the etiological agent of a severe, highly lethal disease of swine. Protein domain analysis of the predicted amino acid sequence of the NS4B protein of highly pathogenic CSFV strain Brescia (BICv) identified a putative Toll/interleukin-1 receptor (TIR)-like domain. This TIR-like motif harbors two conserved domains, box 1 and box 2,...

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Identifiers

PMID: 19923180
DOI: 10.1128/JVI.02050-09
PMCID: PMC2812325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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