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The E2 Glycoprotein of Classical Swine Fever Virus Is a Virulence Determinant in Swine

24 Feb 2005

Abstract excerpt

To identify genetic determinants of classical swine fever virus (CSFV) virulence and host range, chimeras of the highly pathogenic Brescia strain and the attenuated vaccine strain CS were constructed and evaluated for viral virulence in swine. Upon initial screening, only chimeras 138.8v and 337.14v, the only chimeras containing the E2 glycoprotein of CS, were attenuated in swine despite exhibiting unaltered...

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PMID: 15731272
DOI: 10.1128/jvi.79.6.3787-3796.2005

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