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Article

Recoding structural glycoprotein E2 in classical swine fever virus (CSFV) produces complete virus attenuation in swine and protects infected animals against disease.

Virology - 1 Jul 2016

Velazquez-Salinas Lauro, Risatti Guillermo R, Holinka Lauren G, O'Donnell Vivian, Carlson Jolene, Alfano Marialexia, Rodriguez Luis L, Carrillo Consuelo, Gladue Douglas P, Borca Manuel V

Abstract excerpt

Controlling classical swine fever (CSF) mainly involves vaccination with live attenuated vaccines (LAV). Experimental CSFV LAVs has been lately developed through reverse genetics using several different approaches. Here we present that codon de-optimization in the major CSFV structural glycoprotein E2 coding region, causes virus attenuation in swine. Four different mutated constructs (pCSFm1-pCSFm4) were designed...

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PMID: 27110709
DOI: 10.1016/j.virol.2016.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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