Article
Repression of basal transcription by vitamin D receptor: evidence for interaction of unliganded vitamin D receptor with two receptor interaction domains in RIP13delta1.
Journal of molecular endocrinology - 1 Jun 1998
Dwivedi P P, Muscat G E, Bailey P J, Omdahl J L, May B K
Abstract excerpt
Repression of basal transcription of a 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) responsive 25-hydroxyvitamin D3-24-hydroxylase (CYP24) promoter construct as observed in kidney cells in the absence of ligand and this repression was dependent on a functional vitamin D response element (VDRE). Basal...
Topics
- Animals
- Base Sequence
- Binding Sites
- COS Cells
- Calcitriol
- Cell Line
- Consensus Sequence
- Cytochrome P-450 Enzyme System
- DNA Primers
- Enzyme Repression
- Genetic Variation
- Humans
- Kidney
- Promoter Regions, Genetic
- Receptors, Calcitriol
- Recombinant Fusion Proteins
- Restriction Mapping
- Steroid Hydroxylases